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Symbol
Name
ID

Cacna1g
calcium channel, voltage-dependent, T type, alpha 1G subunit
MGI:1201678

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Dysphagia

Spastic gait

Atrophy/Degeneration affecting the brainstem

Hyperintensity of cerebral white matter on MRI

Abnormal cerebellum morphology

Cerebellar vermis atrophy

Loss of Purkinje cells in the cerebellar vermis

Cerebellar atrophy

Alzheimer disease

Ataxia

Gait ataxia

Spastic ataxia

Tremor

Upper limb postural tremor

Resting tremor

Head tremor

Abnormal pyramidal sign

Babinski sign

Dysarthria

Depression

Cognitive impairment

Hyperreflexia

Unsteady gait

Eyelid myokymia

Reduced brain N-acetyl aspartate level by MRS

Neurodevelopmental abnormality

Impaired vibration sensation at ankles

Disease(s) Associated with CACNA1G

cerebellar ataxia type 42

Mouse Phenotypes

decreased susceptibility to pharmacologically induced seizures

abnormal spike wave discharge

abnormal cerebellar cortex morphology

Purkinje cell degeneration

thin cerebellar molecular layer

astrocytosis

neurodegeneration

abnormal nervous system physiology

abnormal action potential

impaired ability to fire action potentials

abnormal afterhyperpolarization

abnormal single cell response

abnormal neuron physiology

abnormal channel response

Availability

Mouse Genotype

Cacna1g^em1Ftan/Cacna1g^em1Ftan

Cacna1g^tm1.1Stl/Cacna1g^tm1.1Stl

Cacna1g^tm1.3Ksak/Cacna1g^tm1.3Ksak

Cacna1g^tm1Hssh/Cacna1g^tm1Hssh

Cacna1g^em1Ftan/Cacna1g⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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